Dr. Sarah Wiethoff

Dr. Dr. Sarah Wiethoff

Medical Doctor and Scientist

Institute of Neurology, University College London, and the Center of Neurology, Hertie Institute, University Hospital Tübingen

Sarah Wiethoff is a German neurologist and neuroscientist working between the Institute of Neurology, University College London, and the Center of Neurology, Hertie Institute for Clinical Brain Research and Clinic of Neurology at the University Hospital Tübingen.

As a medical doctor and scientist, her work focuses on clinicogenetic and cellular aspects of inherited neurodegenerative diseases. Neurodegenerative diseases, where incurable degeneration of neurons results in progressive health problems, are equally fascinating as they are devastating, illustrating both function and pathology of neurons, the most complex cells in our body. Despite recent technological breakthroughs, for many patients with different neurodegenerative diseases, no genetic diagnosis can be established. For another significant proportion of neurodegenerative diseases the genetic defect and the resulting clinical spectrum might be known, but knowledge about exact pathomechanisms remain elusive. This delays successful translational research and eventual clinical treatment. Sarah Wiethoff’s interdisciplinary work improves clinical characterisation and genetic analysis of patients with neurodegenerative diseases by identifying underlying genetic causes and modifiers of disease. By generating novel disease models using stem cell technology it aims to shed light on pathogenic and potentially druggable mechanisms of disease in order to improve therapy for those relentless and to date remediless conditions.